A Comparative Study of Ashokarishtam and Clomiphere Citrate in Combating Polycystic Ovary Syndrome Induced Oxidative Stress in Rat
نویسندگان
چکیده
Body has defense mechanisms against oxidants in the form of both enzymatic and non enzymatic antioxidants. Oxidants have both physiological and pathological role in female reproduction. Oxidative stress causes damage to the ovaries, oogonia and ovulation as well as in implantation procedures. A study was undertaken to evaluate the polycystic ovary syndrome (PCOS) induced stress in ovarian and uterine tissues and to compare the protective effect of clomiphene citrate and ashokarishtam. Elevated levels of malondialdehyde (37.99 ± 0.88 to 63.08 ± 1.09 mg/g/tissue) and myeloperoxidase (01.59 ± 0.14 to 02.61 ± 0.18 H202 lib/nm/mt/ mgptn) in ovary and uterus were observed in PCOS induced rat. After ashokarishtam treatment it displayed decreased levels of (p<0.001) malondialdehyde and myeloperoxidase in ovary (33.83 ± 0.69 mg/g/tissues) and uterus (01.12 ± 0.15 H2O2 lib/nm/mt/mgptn). However, clomiphene citrate treatment never resulted in such significant decrease of either malondialdehyde or myeloperoxidase. Study showed significant rise of reduced glutathione (p<0.001 level) in ovary and uterus after ashokarishtam treatment. Clomiphene citrate could increase the antioxidant only up to p<0.01 level. The study shows the extent of oxidative stress in ovarian and uterine tissues as indicated by increased levels of malondialdehyde and myeloperoxidase and decreased level of the antioxidant glutathione.
منابع مشابه
The Effect of Green Tea Extract on Reproductive Improvement in Estradiol Valerate-Induced Polycystic Ovary Polycystic Ovarian Syndrome in Rat
Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder in which thelevel of oxidative elements in blood rises. Green tea is a potent antioxidant since it containscatechins. In this study, the effect of hydro-alcoholic green tea extract on PCOS rats was examined.For PCOS induction, 96 mature Wistar rats were given estradiol valerate. After 60 days, therats were divided into fo...
متن کاملThe Effect of Green Tea Extract on Reproductive Improvement in Estradiol Valerate-Induced Polycystic Ovary Polycystic Ovarian Syndrome in Rat
Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder in which thelevel of oxidative elements in blood rises. Green tea is a potent antioxidant since it containscatechins. In this study, the effect of hydro-alcoholic green tea extract on PCOS rats was examined.For PCOS induction, 96 mature Wistar rats were given estradiol valerate. After 60 days, therats were divided into fo...
متن کاملRole of Oxidative Stress in Polycystic Ovary Syndrome
Introduction: Polycystic ovary syndrome is one of the most common causes of infertility. 6 to 8 percent of women of childbearing age have this endocrine disorder. Biochemical abnormalities in these patients lead to imbalance of female hormones and increased androgens, which can have consequences such as menstrual cycle disorder, hirsutism, acne vulgaris and androgenic alopecia. Despite the long...
متن کاملP-38: Comparison of Oxidative Stress and Antioxidative Status in non Obese Women with and without Polycystic Ovary Syndrome
متن کامل
Effects of Salvia officinalis L. (common sage) leaves tea on insulin resistance, lipid profile, and oxidative stress in rats with polycystic ovary: An experimental study
Objective: Oxidative stress conditions and metabolic complications are common among polycystic ovary syndrome (PCOS) patients. There are various reports about hypoglycemic and antioxidant effects of Salvia officinalis L. (common sage). This study evaluated the possible medicinal effects of sage tea drinking on oxidative status, lipid profile, and insulin resistance in ...
متن کامل